Ivermektin potrjen kot potencialni inhibitor razmnoževanja virusa Covid-19

V Nature Communications Biology je bila objavljena nova študija ameriško-kanadskih raziskovalcev (Mody et al, 2021), ki preučuje nekaj že obstoječih zdravil kot možnih inhibitorjev razmnoževanja virusa Covid-19 (SARS-CoV-2). Med drugim ugotavlja, da je ivermektin zelo učinkovit (> 90%) pri zaviranju glavnega encima (3CLpro), ki sodeluje pri razmnoževanju SARS-CoV-2 (in drugih virusov RNA). To tudi lahko pojasni, zakaj je ivermektin tako zelo učinkovit tudi kot profilaksa (preventiva) proti okužbi s SARS-CoV-2.

Mimogrede, 100 tablet 12 mg ivermektina, ki zadostuje za zdravljenje do 50 ljudi, stane na indijskem trgu približno 50 USD. V Indiji je ivermektin že od junija sestavni del protokolov za preventivo in zdravljenje bolnikov s Covid. V Evropi sta zaenkrat Madžarska in Slovaška sprejeli ivermektin kot uradno zdravilo za Covid in šle v nabavo večjih količin.

Spodaj je povzetek članka Mody et al, 2021):

Emerging outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a major threat to public health. The morbidity is increasing due to lack of SARS-CoV-2 specific drugs. Herein, we have identified potential drugs that target the 3-chymotrypsin like protease (3CLpro), the main protease that is pivotal for the replication of SARS-CoV-2. Computational molecular modeling was used to screen 3987 FDA approved drugs, and 47 drugs were selected to study their inhibitory effects on SARS-CoV-2 specific 3CLpro enzyme in vitro. Our results indicate that boceprevir, ombitasvir, paritaprevir, tipranavir, ivermectin, and micafungin exhibited inhibitory effect towards 3CLpro enzymatic activity. The 100 ns molecular dynamics simulation studies showed that ivermectin may require homodimeric form of 3CLpro enzyme for its inhibitory activity. In summary, these molecules could be useful to develop highly specific therapeutically viable drugs to inhibit the SARS-CoV-2 replication either alone or in combination with drugs specific for other SARS-CoV-2 viral targets.

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